Dysfunctional Striatal Systems in Treatment-Resistant Schizophrenia
نویسندگان
چکیده
منابع مشابه
Dysfunctional connectivity in schizophrenia.
Our understanding of brain function has developed considerably since the advent of cognitive neuroscience and functional neuroimaging. Apparently, there are two central principles that functional brain architectures conform to: functional specialisation and functional integration. The former posits that brain systems are specialised for various perceptual and cognitive functions, and the latter...
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We read with interest the report on efficacy of electro convulsive therapy (ECT) in treatment resistant schizophrenia (Goswami et al 2003). A substantial proportion of patients with schizophrenia remain resistant to treatment. Hence a need for additional/alternative treatments in such situations is strongly felt by psychiatrists. Authors' effort to address this issue is therefore timely and wel...
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Since the introduction of chlorpromazine, the first antipsychotic drug, it has been evident that a large number of patients have schizophrenia that is treatment resistant. It is estimated that between 20% and 60% of patients have schizophrenia that is resistant to treatment.1,2 The relationship between treatment-resistant and treatment-responsive schizophrenia is not strictly black and white. N...
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Schizophrenia is a disabling mental illness with a lifetime prevalence of 0.7% worldwide and significant, often devastating, consequences on social and occupational functioning. A range of antipsychotic medications are available; however, suboptimal therapeutic response in terms of psychotic symptoms is common and affects up to one-third of people with schizophrenia. Negative symptoms are gener...
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A systematic approach to the evaluation and characterization of treatment resistance in schizophrenia has become increasingly important since the introduction of clozapine, risperidone, and olanzapine. The need for accurate evaluation will increase with the introduction of the next generation of antipsychotic medications. People with schizophrenia may manifest a poor response to therapy seconda...
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ژورنال
عنوان ژورنال: Neuropsychopharmacology
سال: 2015
ISSN: 0893-133X,1740-634X
DOI: 10.1038/npp.2015.277